Kanade Kirita, S. Hosokawa
Jan 24, 2020
Citations
0
Influential Citations
2
Citations
Journal
The Journal of organic chemistry
Abstract
A short step total synthesis of karrikinolide has been achieved. The both α and α' positions of O-acylated acetol were alkylated by the boron-mediated aldol type acetal addition reaction. One pot sequence including the Arbuzov reaction, intramolecular Horner-Wadsworth-Emmons reaction, acidic hydrolysis of acetals, and pyran formation provided karrikinolide. This procedure was applicable to gram-scale synthesis of karrikinolide.