K. Kobayashi, Daisuke Iitsuka, H. Konishi
Jun 1, 2008
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0
Influential Citations
3
Citations
Journal
Synthesis
Abstract
A facile two-step preparation of the title pyridothiazine derivatives starting from commercially available 2-chloro-6-methylpyridine-3-carbonitrile is described. The reaction of this nitrile with magnesium enolates of tertiary acetamides affords ( Z)-3-amino-3-(2-chloro-6-methylpyridin-3-yl)propenamide derivatives, which in turn are allowed to react with isothiocyanates in the presence of sodium hydride to give the desired products in satisfactory yields.