Y. C. S. Kumar, M. P. Sadashiva, K. Rangappa
Jun 25, 2007
Citations
0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
2-(1-Methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine is useful for synthesizing potent antimicrobials including the arecoline derivatives, phendimetrazine and polygonapholine and was synthesised in nine steps with an overall yield of 36%. Bromination of 3-acetylpyridine and dehydration of a diol with cyclization were pivotal to the success of the strategy.