K. Takatori, S. Toyama, Shoko Narumi
2004
Citations
0
Influential Citations
3
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
l-[3-13C]Alanine was synthesized from [13C]methyl iodide by using Dellaria's oxazinone, prepared from phenyl[2-13C]bromoacetate and (S)-2-phenylglycinol, as a chiral glycine equivalent. Alkylation of the oxazinone with [13C]methyl iodide was achieved with high diastereoselectivity. Hydrolysis and removal of the chiral auxiliary of the alkylated oxazinone gave l-[3-13C]alanine. Copyright © 2003 John Wiley & Sons, Ltd.