Lili Wen, Zhao Jun-ying
2006
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Journal
Journal of Zhengzhou University
Abstract
The preparation of chiral drugs is a significant field of new drug research and application at present.L-(2R,3R)-(-)-dibenzoyl tartaric acidmonohydrate is an important resolute reagent with a high price.So,it is vital to study the improvement of its synthesis. Dibenzoyl tartaric anhydride was synthesized from tartaric acid,benzoic acid and thionyl chloride as raw material by benzoylation and dehydration.Then,dibenzoyl tartaric acid monohydrate could be obtained by hydrolysis.The total yield reached 70.9% calculated from tartaric acid. Benzoic acid that created by the reaction could be re-applied by benzoylation with thionyl chloride in this process.The process has the advantages of high yield and simple operation.Structure of the resultants was identified by optical rotation which agreed with the literature.The process condition was easy to control,and there was little pollution.This method had a good prospect of industrial application.