Eung-Seok Lee, J. Jurayj, M. Cushman
1994
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron
Abstract
Abstract tert-Boc-L-3-Deoxymimosine (13) and tert-Boc-D-Deoxymimosine (16) were prepared in two steps from tert-Boc-L-asparagine and tert-Boc-D-asparagine, respectively. Both 13 and 16 were determined to be optically pure by derivatization with Marphey's reagent. Activation and coupling of 16 to L-isoleucine methyl ester resulted in a diastereomeric mixture of products containing 96% of the DL diastereomer and 4% of the LL diastereomer. [L-3-Deoxymimosine4]-angiotensin I was synthesized from 13 as an approach to the design and synthesis of selective protein-tyrosine kinase (PTK) inhibitors.