W. Xiao
2006
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Journal
Chinese Journal of Pharmaceuticals
Abstract
L-651582, an antiproliferative agent was synthesized from 3,5-dichlorobenzoic acid by reduction, protection, acylation, deprotection and chlorination to give 3,5-dichloro-4-(4-chlorobenzoyl)benzylchloride, which subjected to azidation and cyclization with cyanoacetamide in 32% overall yield.