D. Dischino, V. Gribkoff, P. Hewawasam
Feb 1, 2003
Citations
1
Influential Citations
8
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The syntheses of tritium labeled (S)-3-(5-chloro-2-[OC3H3]methoxyphenyl-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one, and carbon-14 (S)-3-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-[2,3-14C2] indol-2-one are reported. The 3H-labeled compound was prepared in a two-step synthesis from C3H3I. The final product was purified via chiral HPLC to yield the desired enantiomer in a 4% radiochemical yield and a specific activity of 60 Ci/mmol. The 14C-labeled compound was prepared in a four-step synthesis from diethyl [carboxylate-14C1,2] oxalate. The final product was purified via chiral HPLC to yield the desired enantiomer in a 20% radiochemical yield and a specific activity of 28.4 μCi/mg. Copyright © 2002 John Wiley & Sons, Ltd.