P. Allevi, A. Longo, M. Anastasia
Nov 1, 1999
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A synthetic route for obtaining highly pure methylmalonic and propionic acids labelled at the methyl groups is validated by the preparation of methyl-d3-malonic and propionic-3,3,3-d3 acids. The synthesis involves the alkylation of the diethyl allylmalonate with iodomethane-d3, deallylation of the resulting diethyl allylmethyl-d3-malonate by treatment with (η2-propene)Ti(O-i-Pr)2 and hydrolysis. Decarboxylation of the obtained methyl-d3-malonic acid affords propionic-3,3,3-d3 acid. Copyright © 1999 John Wiley & Sons, Ltd.