H. Lammers, R. Vollinga, P. Zandbergen
May 1, 1995
Citations
0
Influential Citations
2
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Treatment of 4-substituted 3,5-dimethyl-1-nitro-1H-pyrazoles 1 and 10a-c with secondary amines in acetonitrile, in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), affords the novel dialkyl-aminomethyl-1H-pyrazoles 5, 6, 7, 8, 11a-c, 12a-c and 13a-c in good to excellent yields. In this way one of the, in general, inert methyl groups of 3,5-dimethyl-4-substituted-1H-pyrazoles is functionalized creating a new synthetic route to azoles containing a coordinating substituent.