Lin Yuan
2006
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Lamotrigine was synthesized from 2,3-dichlorotoluene by oxidation with HNO3, reaction with thionyl chloride and then cyanidation to give 2,3-dichlorobenzoyl cyanide, which was subjected to reaction with aminoguanidine bicarbonate followed by cyclization with an overall yield of about 12%.