G. A. Erickson, Jiasheng Guo, M. Mcclure
Oct 22, 2014
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A new synthesis of Lapatinib, an orally active drug for breast cancer, is described. The synthesis involves a palladium catalyzed regioselective arylation of furfural with 6-bromo- N -(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinazolin-4-amine. This key step replaces an atom inefficient Suzuki cross coupling reaction used in a previously disclosed route and significantly shortens the synthesis.