Mickaël Jean, M. Le Roch, J. Renault
Jun 1, 2005
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Influential Citations
8
Citations
Journal
Organic letters
Abstract
[reaction: see text] A polyamine derivative was prepared from alpha-methylene-gamma-butyrolactone. This method used Michael addition and lactone aminolysis followed by the nucleophilic substitution of the hydroxyl group by an azido group. The coupling of a lipophilic alkyne led to a polyamine that will be probed as a gene transfer agent.