Mao Zhenmin
2010
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
N-Boc-L-glutamine(2) was subjected to intramolecular cyclization and deprotection to give the intermediate 3-amino-2,6-piperidinedione trifluoroacetate(4).The other intermediate methyl 2-bromomethyl-3nitrobenzoate(6) was obtained from 2-methyl-3-nitrobenzoic acid methyl ester(5)via bromination.Compound 4 and 6 underwent condensation,followed by reduction to give lenalidomide with an overall yield of about 33%(based on compound 5).