Xiaozhong Fan
2012
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Research and Exploration in Laboratory
Abstract
A promoted route to synthesizing letrozole was introduced.Using chlorobenzonitrile as reactants,the preparation of letrozole acetate was improved.The factors which influence the reactive performance of letrozole acetate were investigated and optimized,including reaction temperature of each step.The results indicate that the best reaction conditions are as follows: The temperature is 60 ℃,when synthesizing compound 1,the temperature is 55 ℃,when synthesizing compound 2,and the temperature should be controlled to 0 ℃ by ice-water system,when synthesizing compound 3.The improved experiment is cheap,easy to operate,and productive.It has instructional significance for industrial production and experimental teaching.