G. Tong, J. Perich, R. Johns
1990
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Boc-Asp-O t -Bu was efficiently converted to Boc-Abu(PO3Me2)-O t -Bu in five steps then to Boc-Abu(PO3Me2)-OH in two steps. Both the protected amino acids were used in the syntheses of Boc-Leu-Abu(PO3Me2)-O t -Bu and Boc-Glu(OBzl)-Abu(PO3Me2)-Leu-OBzl by the Boc mode of peptide synthesis. These were deprotected to Leu-Abu( P ) and Glu-Abu( P )-Leu by hydrogenolysis followed by bromotimethylsilane treatment.