F. Babudri, V. Fiandanese, O. Hassan
Apr 23, 1998
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron
Abstract
Abstract A new synthesis of leukotriene B3 methyl ester is reported, starting from bis(trimethylsilyl) unsaturated derivatives as building blocks for the triene moiety of the leukotriene. The two stereogenic centers have been generated by enantioselective chemical reduction of two acetylenic ketones with both R- or S-Alpine BoraneR. The three conjugated double bonds system of the leukotriene has been assembled by Miyaura-Suzuki cross-coupling reaction.