Dongmei Li, Liping Song, Xianfu Li
Jul 1, 2007
Citations
0
Influential Citations
21
Citations
Journal
European Journal of Organic Chemistry
Abstract
One-pot, three-component condensation reactions of aromatic aldehydes 1, 3-methylpyrazol-5-one (2) and ethyl trifluoroacetoacetate (3) provided an efficient methodology for the preparation of ethyl (4S*,5R*)-4-aryl-6-hydroxy-3-methyl-6-(trifluoromethyl)-2,4,5,6-tetrahydropyrazolo[3,4-b]pyran-5-carboxylate derivatives (4). The reactions gave moderate to good yields under mild conditions. These new products 4 were fully characterized by spectral methods and single-crystal X-ray diffraction analysis. A plausible reaction pathway for the formation of 4 is presented. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)