Choh Hao Li, E. Schnabel, D. Chung
Jan 14, 1961
Citations
0
Influential Citations
29
Citations
Journal
Nature
Abstract
THE occurrence of the heptapeptide, L-methionyl-L-glutamyl-L-histidyl- L-phenylalanyl-L-arginyl-L-tryptophyl-glycine, in both adrenocorticotropins (ACTH) and melanotropins (MSH)1–3 has led to synthesis of various peptides4–7 related to all or part of this amino-acid sequence. In recent reports8 the synthesis of the glutamine analogue of this heptapeptide has been described, and it was shown to possess corticotropin-releasing (CRF) activity. In the course of the synthesis of a nonadecapeptide9 which has a sequence identical with the first 19 amino-acid residues of ACTH and which possesses ACTH and MSH activity, we have synthesized the heptapeptide in its natural form and found it to have both MSH and CRF activity.