Xu Li-feng
2011
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Journal
Journal of Liaoning University
Abstract
Quinazoline derivatives are a class of compounds with good biological activity of nitrogen containing heterocyclic compounds.In this article,the intermediate 2-amino-4-chlorobenzamide was synthesized from 4-chloro-2-nitrobenzoic acid,through esterification with methanol,followed by amidation with ammonium hydroxide,reduction with Iron powder and hydrochloric acid.2-amino-4-chlorobenzamide reacted with 4-(trifluoromethyl) benzoyl chloride to afford 7-chloro-2-(4-(trifluoromethyl) phenyl)quinazolin-4(3H)-one.The target compound 7-morpholino-2-(4-(trifluoromethyl) phenyl) quinazolin-4(3H)-one was synthesized through a condensing reaction between the intermediate 7-chloro-2-(4-(trifluoromethyl) phenyl) quinazolin-4(3H)-one and morpholine.The total yield of 9 is 34.90%.The structure of the target compound was confirmed by IR and 1HNMR.