Fang Ling
2011
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Journal
Drugs and Clinic
Abstract
Objective To study the synthetic technology of(2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol.Methods 3-Pentanone was taken as the starting material,(2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol was obtained after a series of chemical reactions including Mannich reaction,resolution,Grignard reaction,and so on.At the same time,the procedure of chiral resolution was optimized.Results(2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol was synthesized with an overall yield of 30.6%.Conclusion The improved procedure can increase the yield of product and reduce the waste of raw material.