Feng Bo-cheng, Pan Peng-yong, Tang Lin-sheng
2004
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Journal
Journal of Qingdao University of Science and Technology
Abstract
The synthesis of 1-bromo-4-n-pentyl benzene was studied using bromobenzene, n-pentoyl chloride and hydrazine hydrate as starting materials through Friedel-Crafts reaction and Wolff-Kishner-Huang reduction. The optimum conditions of Friedel-Crafts reaction are as follows: n(n-pentoyl chloride)∶n(bromobenzene)∶n(aluminum chloride) =1∶2∶1.4, reaction time 5 h, reaction temperature 30~35 ℃.The optimum conditions of Wolff-Kishner-Huang reduction are as follows: n(1-bromo-4-n-pentanone benzene)∶n(hydrazine hydrate)∶n(potassium hydroxide)=1∶1.1∶0.2, reaction temperature 180~(190 ℃, )reaction time 3~4 h. Under above conditions, the final yield of 1-bromo-4-n-pentyl benzene was about 40%, the purity was 99.3%.