P. Dong
2003
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Lomerizine hydrochloride was synthesized from bromo bis(4 fluorophenyl)methane by consecutive condensation with piperazine and 2,3,4 trimethoxybenzaldehyde to obtain the product of cry stal typeⅡ, which underwent crystal transformation by recrystallization in acetonitrile to get the effi cacious crystal of typeⅠ in an overall yield of 25%.