Zhou Ping
2003
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Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To synthesize Lomerizine hydrochloride,a new drug for the treatment of antimigraine. METHOD Lomerizine hydrochloride was synthesized via Leuckart Wallach reaction.RESULTS The reaction was modified and improved,the yield was 56.9%.The structure of title compound was confirmed by IR, 1H NMR,MS and elemental analysis data.CONCLUSION The process can be easily controlled and is suitable for a scale production.