Przemysław Aksamitowski, K. Wieszczycka, A. Wojciechowska
Feb 14, 2017
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Abstract
N’-hydroxy-N-alkylpyridinecarboximidamides are new class of N-substituted imidamide derivatives, with diverse potential applications. In this study, the synthesis of novel long-chain N-substituted pyridinecarboximidamides: N’-hydroxy-N-alkylpyridinecar-boximidamides and N’-hydroxy-N,N-dialkylpyridinecarboximidamides is reported. The two methods were proposed and compared: (I) the two-step procedure (synthesis of N-alkylpyri-dinecarboximidamide and next N'-hydroxy-N-alkylpyridinecarboximidamide) and (II) the three-step procedure (synthesis from pyridineamidoxime by pyridinehydroximoyl chloride and finally preparation of N'-hydroxy-N-alkylor -N,N-dialkylpyridinecarboximidamide). It was indicated that only the three-step procedure enabled the efficient synthesis of the N'-hydroxy-N,N-dialkylpyridinecarboximi-damide with the substituent at position 3 and 4 of the pyridine ring.