O. Pingkai
2005
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Journal
Fine chemicals
Abstract
L-Prolinol was obtained from L-proline by direct reduction with NaBH_4 /I_2 system.The optimal reaction conditions in large-scale preparation are as follows.Reduction was performed by refluxing 20 h with n(NaBH_4):n(I_2):n(L-proline)=2.5∶1.75∶1 after dropping addition of I_2 solution at room temperature.Hydrolysis was carried out with w(NaOH)=20 % solution at 90 ℃ for 3 h.Yield of L-prolinol reached 88.4% and the enantiomerical purity of L-prolinol was up to 99%.