Jiao Qing-cai
2005
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0
Influential Citations
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Citations
Journal
Fine chemicals
Abstract
Protected L-glutamic acid was prepared using inexpensive phthaloyl as protecting group.Then N-phthaloyl-L-glutamic acid anhydride was synthesized with protected L-glutamic acid and acetic anhydride under reflux for 10 minutes.Under ambient temperature and pressure,N-phthaloyl-L-theanine and N-phthaloyl-L-glutamine were produced by reaction of N-phthaloyl-L-glutamic acid anhydride with 2 mol/L ethylamine solution and 2 mol/L ammonia solution respectively.Subsequently,the phthaloyl group was removed from the intermediates with 0.5 mol/L hydrazine hydrate under ambient temperature for 48 h.As a result,L-theanine and L-glutamine were obtained in 61% and 57% yields respectively.