V. A. Vydrina, K. S. Denisova, M. P. Yakovleva
Dec 1, 2020
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Journal
Russian Journal of Organic Chemistry
Abstract
Efficient methods have been developed for the synthesis of three potentially useful macroheterocycles containing pyridine-2,6-dicarboxylic and adipic acid ester and hydrazide fragments starting from tetrahydropyran (commercial petrochemical product) through intermediate 8-hydroxyoctan-2-one. The key stages were [2+1]-condensation of the latter with pyridine-2,6-dicarboxylic and adipic acid chlorides and [1+1]-condensation of the resulting α,ω-diketo diesters with dihydrazides derived from the same diacids. The structure of the synthesized compounds was confirmed by IR, NMR, and mass spectra.