S. Narita, Tetsuhiro Ogura, Toyonobu Usuki
2013
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0
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1
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Journal
Journal of Chemistry
Abstract
Magnolignan, 2,2′-dihydroxy-5,5′-dipropyl-biphenyl (1), is a down-regulator of melanin synthesis that inhibits the maturation of tyrosinase. In this study, a concise total synthesis of 1 was achieved in five steps with 50% overall yield starting from commercially available trans-anethole (2) via a Suzuki-Miyaura reaction.