N. B. Malkar, G. Fields
2004
Citations
0
Influential Citations
2
Citations
Journal
Letters in Peptide Science
Abstract
N α-(fluoren-9-ylmethoxycarbonyl)-N ε-[(7-methoxycoumarin-4-yl)acetyl]-L-lysine[Fmoc-Lys(Mca)-OH] has been conveniently prepared. The copper complex of L-lysine hydrochloride was initially prepared, followed by the addition of the (7-methoxycoumarin-4-yl)acetyl (Mca) group to the ε-amino group. The copper complex was decomposed, and the Fmoc group was introduced to the α-amino group. Fmoc-Lys(Mca)-OH was recrystallized from hexane and could be used directly for the solid-phase synthesis of fluorogenic substrates.