Yonghua Liu, L. Zhang, Yanxing Jia
Feb 8, 2012
Citations
0
Influential Citations
32
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The total synthesis of maremycins A, B, C 1 /C 2 , D 1 , and D 2 is achieved starting from the natural amino acids l -isoleucine and S -methyl- l -cysteine, in which the total synthesis of maremycins B, C 1 /C 2 , and D 2 is accomplished for the first time. The synthesis features a position-selective intramolecular bromination process for the synthesis of key chiral building block, a Pd-catalyzed indole synthesis for the preparation of (2 S ,3 S )-β-methyltryptophan and hydroxylation of oxindoles by molecular oxygen. In addition, the protocol for conversion of maremycins A and B to maremycins C and D was improved.