G. Sunilkumar, D. Nagamani, N. Argade
Nov 1, 2003
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Influential Citations
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Journal
Synthesis
Abstract
A five-step synthesis of marine natural product (2S,5S)-pyrrolidine-2,5-dicarboxylic acid (1) has been described starting from methyl ester of BOC-protected (S)-proline via stereoselective electrochemical oxidation with introduction of the methoxy group at C 5 -position by S N 2-substitution of the cyano group followed by hydrolysis in 13% overall yield.