Arnaud Martin, B. Figadère, S. Saivin
Jun 1, 2000
Citations
0
Influential Citations
4
Citations
Journal
Arzneimittelforschung
Abstract
Summary The first synthesis of the methylamino-2-phenyl-2-butyl-3,4,5-trimethoxybenzoate (desmethyl-trimebutine) I is described. This compound is the main bioactive metabolite of trimebutine II (Debridat®, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969. It was used for pharmacokinetic and bioequivalence studies.