Fan Li
2008
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Journal
Chinese Journal of New Drugs
Abstract
Objective: To design and synthesize meclizine hydrochloride.Methods: Using 1-(chloromethyl)-3-methylbenzene(Ⅰ) and piperazine(Ⅱ) as the starting materials,1-[(3-methylphenyl)methyl] piperazine dihydrochloride(Ⅲ) was synthesized.Then Ⅲ reacted with(4-chlorophenyl)phenymethyl chloride(Ⅳ) to produce meclizine(Ⅴ),and finally obtained the title compound meclizine hydrochloride(Ⅵ) by acidifying with hydrochloric acid.Results and Conclusions: The structure of the target compound was identified by mp,IR,1HNMR,13CNMR,MS and element analysis.This new synthetic scheme can be industrialisated because of the advantages of a lower cost,higher yield(81.8%),simpler operation,and milder reaction conditions.