W. Fei
2001
Citations
0
Influential Citations
0
Citations
Journal
Fine chemicals
Abstract
The synthesis of 5 amino 2,4,6 triiodoisophthalic acid,which is used as intermediate for nonionic iodinated X ray contrast agents,is described in this paper.5 Amino 2,4,6 triiodoisophthalic acid was synthesized from isophthalic acid by a three step procedure,nitration,reduction and iodination.(1)Nitration:at n (sulfuric acid)∶ n (sodium nitrate)∶ n (isophthalic acid)=7 9∶2 2∶1 0 after reacting at 60 ℃ for 3 h,the yield of nitro compound was 86.7%.(2)Reduction:at n (iron)∶ n (nitro compound)=3.0∶1 0 after refluxing for 3 h,the yield of amino compound was 78.1%.(3)Iodination:at n (ICl)∶ n (amino compound)=3 3∶1 0 after heating at 90 ℃ for 3 h,the yield of iodination product was 76 2%.The overall yield was 51 6%.Melting point and UV,IR, 1HNMR and 13 CNMR spectra of the prepared product were identical with those reported in the literatures.