Bhaskar Kandagatla, V. V. N. K. V. P. Raju, G. Reddy
Dec 26, 2012
Citations
0
Influential Citations
9
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C–C bond formation by nitroaldol and Pd/C hydrogenation of β-nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine.