Z. Rothschild, R. Schayer
Oct 1, 1958
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0
Influential Citations
41
Citations
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Journal
Biochimica et biophysica acta
Abstract
Abstract A new synthesis is described for 1-methyl-4-(β-aminoethyl)-imidazole, a major metabolite of histamine. This compound was also prepared in radioactive form by biosynthesis and by chemical synthesis. When 1-methyl-4-(β-aminoethyl)-imidazole is injected into mice, a major portion is oxidized to 1-methylimidazole-4-acetic acid. Both compounds were determined quantitatively in urine using isotope dilution procedure. A study of the effect of inhibitors on this oxidation in intact mice indicated that diamine oxidase plays little or no role. The enzyme involved was inhibited by a monoamine oxidase inhibitor.