F. Toudic, N. Plé, A. Turck
Jan 7, 2002
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron
Abstract
Abstract The regioselective metallation of 2-fluoropyrazine allowed the synthesis of various 5- and 6-iodofluoropyrazines. Use of cross-coupling reactions with iodofluoropyrazines under Suzuki or Negishi conditions led to aryl and alkylfluoropyrazines. The benzylfluoropyrazines have been used as building block to synthesize a wide range of arylbenzylfluoropyrazines which could exhibit mesomorphic properties.