L. Chun
2000
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Journal
Journal of China Pharmaceutical University
Abstract
In this paper we present a new simple synthesis method of 1 benzenemethyl piperidine 4 carboxylic acid, which was prepared from N,N bis(2 hydroxyethyl) amine by N hydrocarbylation, chloridization, cyclic addition and hydrolysis. The operation method of compound Ⅲ was improved. The operation of the every step reaction was simple, and the yield of the method increased by 10% or more as compared with the yield in literature.