Zhou Ru
2004
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Journal
Chemical Reagents
Abstract
A new method of synthesizing 2 chloromethyl thiophene,substituting formalin by formaldehyde,was studied.The influence of temperature,reaction time and reactant ratio on the reaction was discussed.The technological parameters optimized by orthogonal test were as follows:reaction temperature -5℃,reaction time 2.5h,reactant ratio(thiophene:hydrochloride:formaldehyde)1∶1.4∶1.3.The yield of 2 chloromethyl thiophene under this condition was 65.1%.