Xu Yun-gen
2005
Citations
0
Influential Citations
0
Citations
Journal
Progress in Pharmaceutical Sciences
Abstract
Objective: To improve synthesis method of a key intermediate for Rosiglitazone, 4-[2-(methyl-pyridin-2-yl-amino)-ethoxy]-benzaldehyde. Methods: 2-(methyl-pyridin-2-yl-amino)-ethanol reacted with 4-fluorobenzaldehyde, using acetonitrile as solvent and KOH as disacidifing agent, and with 4-hydroxybenzaldehyde respectively to obtain target compound. Results: The structure of target compound obtained was confirmed by ()~(1)HNMR and MS. Conclusion: The two synthesis methods improved are easy and suitable for industrial manufacturing.