H. Rakoff
Mar 1, 1993
Citations
0
Influential Citations
2
Citations
Journal
Lipids
Abstract
For use in metabolic studies, methyl 11,14,17-eicosatrienoate-3,3,4,4,8,8,9,9-d8 was prepared by Wittig coupling of 3,6-nonadienyltriphenylphosphonium iodide with methyl 11-oxoundecanoate-3,3,4,4,8,8,9,9-d8 in the presence of butyl lithium. Theall cis isomer was separated by high-pressure liquid chromatography using a reverse-phase column. An unexpected by-product, methyl 10,13,16-nonadecatrienoate-2,2,3,3,7,7,8,8-d8, was also isolated. The structures and the configurations of the compounds were confirmed by nuclear magnetic resonance spectroscopy and mass spectrometry.