H. Lim, Y. Song, K. Lee
Mar 18, 2008
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Journal
ChemInform
Abstract
SYNTHESIS 2007, No. 21, pp 3376–3384xx.xx.2007 Advanced online publication: 21.09.2007 DOI: 10.1055/s-2007-990809; Art ID: F13507SS © Georg Thieme Verlag Stuttgart · New York Abstract: Methyl 2-Amino-3H-1-benzazepine-4-carboxylates or methyl 2-(cyanomethyl)-2,3-dihydro-1H-indole-2-carboxylates were prepared from the reaction of 3-[2-formamido-, 2-acetamido-, or 2-(propanoylamino)phenyl]-substituted methyl 2-(cyanomethyl)propenoates with sodium methoxide in methanol, respectively. The latter were readily obtained from the Morita–Baylis–Hillman reaction of N-protected 2-aminobenzaldehydes with methyl acrylate followed by acetylation and cyanation.