Yong Zhang, M. N. A. Khan, P. Gong
Aug 1, 2009
Citations
0
Influential Citations
4
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel–Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride. The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently, which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors.