Tao Feng
2005
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Journal
Jiangsu Chemical Industry
Abstract
Methyl 4-butyrylamino-3-metyl-5-aminobenzoate is an important pharmaceutical intermediate, and this paper presents a convenient process for its synthesis. Methyl 4-butyrylamino-3-metybenzoate was nitrated with the mixture of nitric acid and sulfuric acid to afford the corresponding 5-position nitrated compound, Reduction was performed in the presence of Fe powder, and the total yield amounted to 72%. Factors including ratio of mixed acid, nitration time, reduction temperature and reduction have been investigated, this process exhibits the advantage of low cost and high yield.