Yang Jian-she
2009
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Journal
Journal of Wuhan Institute of Technology
Abstract
Methyl 4-chloro-2-(N-methyl-N-phenylsulphonamide)benzoate(Ⅰ) was an important intermediate of Tianeptine.Starting with 4-Amino-methylbenzene-2-sulfonic acid(Ⅱ),the title compound was prepared through diazotization and Sandmeyer reaction,oxidation,esterification,chlorination,condensation and methylation.The total yield was 44.2%.The improved process was more suitable for industrial production because of higher yield and lower cost.Structure of product was confirmed by IR,MS and1H-NMR.