T. Ernawati, Zulfa Khoirunni’mah
Mar 30, 2015
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0
Influential Citations
5
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Journal
Indonesian Journal of Chemistry
Abstract
Synthesis of methyl nitrophenyl acrylate via modification of methyl trans-cinnamate had been done to improve its biological activity. The reaction of methyl trans-cinnamate with nitrating agent gave methyl 3-(2-nitrophenyl)acrylate and methyl 3-(4-nitrophenyl)acrylate with an ortho/para ratio of 1:8. Its structure was confirmed with 1 H-NMR, 13 C-NMR, FTIR, GC-MS. Biological activity of methyl 3-(4-nitrophenyl)acrylate and methyl 3-(2-nitrophenyl)acrylate assays was performed on Cancer cells against P388 Murine Leukemia with IC 50 = 7.98 μg/mL, IC 50 = 27.78 μg/mL.