Tian Da-kui
2009
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Journal
Journal of Henan Normal University
Abstract
S-2-Benzothiazolyl(Z)-2-(2-Aminothiazol-4-yl)-2-methoxycarbonyl methoxy imino thioacetate(MICA activated thioester),a key intermediate for Cefixime and Carumonam,is synthesized by the esterification reaction of(Z)-2-(methoxycarbonyl methoxyimino)-2-(2-Aminothiazol-4-yl) acetic acid(1) with dibenzothiazolyl disulfide(2) in acetonitrile in presence of P(OEt)3 instead of Ph3 P and Et3N with 60.5% yield.The best molar ratio of(1),(2),(P(OEt)3) and Et3N is 1∶1.2∶1.2∶1.2.The structure of the target compound is confirmed by the its IR and 1HNMR data with that of the standard sample.