A. Miszke, H. Foks, A. Kędzia
Sep 1, 2008
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Journal
Heterocycles
Abstract
Synthesis of 2-mercapto-4-(pyrrolidin-1-yl)pyridine derivatives starting from 2-bromo-4-(pyrrolidin-1-yl)pyridine-3-carbonitrile (1) is described. The desired derivatives of 2-(phenylthio)-4-(pyrrolidin-1-yl)pyridine-3-carbonitrile were obtained in reaction of 1 with suitable thiophenoles, while reaction with benzyl mercaptan gave a related thiobenzyl derivative. Alternatively, compound 1 was transformed into 2-mercapto-4-(pyrrolidin-1l-yl)pyridine-3-carbonitrile (2). Reaction of 2 with chloroacetic acid or chloroacetone derivatives gave related products of mercapto group substitution. The latter compounds could be cyclized in Thorpe-Ziegler reaction to related 3-amino-4-(pyrrolidin-1-yl)thieno[2,3-b]pyridine derivatives. Reaction of 2 with sodium hydroxylamino-O-sulphonate gave the related aminosulfanyl derivative. Selected product were screened for bacteriostatic and antituberculosis activity, and some of them exhibited a significant activity.