Zhang Ming-yu
2012
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Journal
Fine chemicals
Abstract
The mixtures of cis/trans-4-(5′-propyl-tetrahydropyran-2′-yl)-cyclohexane carboxylic acid(3PyHA) were synthesized from trans-4-(5′-propyl-tetrahydropyran-2′-yl)-benzoic acid(3PyPA) by catalytic hydrogenation.The results of hydrogenation condition experiments show that the reaction results were best with Ru/C as catalyst,NaOH solution as reaction medium,and when the reaction temperature was 75~85 ℃ and hydrogenation pressure was 3.5 MPa.A purity of more than 99.5% of trans-4-(5′-propyl-tetrahydropyran-2′-yl)-cyclohexane carboxylic acid(3PyHA) can be obtained by isomerization reaction with high temperature and subsequently by recrystallization with toluene and ethanol.